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Steven Shafer

Academic Appointments

  • Professor of Anesthesiology, Perioperative and Pain Medicine at the Stanford University Medical Center

Contact Information

  • Clinical Offices
    Department of Anesthesiology, Perioperative and Pain Medicine 300 Pasteur Dr MC 5640 H3589 Stanford, CA 94305
    Tel Work (650) 704-0558 Fax (650) 887-2203
  • Academic Offices
    Personal Information
    Email Tel (650) 725-5837
    Not for medical emergencies or patient use

Professional Overview

Bio

My professional interests are the clinical pharmacology of intravenous anesthetic drugs. This has led me to clinical studies of many of the intravenous opioids and hypnotics used in anesthetic practice. However, my passion is not the drugs themselves, but rather the mathematical models that characterize drug behavior. These include conventional pharmacokinetic and pharmacodynamic models, inverse models (used to drive target controlled infusion systems), Bayesian models (used to handle model uncertainty), pharmacokinetic and pharmacodynamic models of drug interaction, models of receptor function that help elucidate mechanisms of drug action, and models that relate drug response to "in silico" pharmacogenetics.

Clinical Focus

  • Anesthesia
  • Regional Anesthesia
  • Total Intravenous Anesthesia

Academic Appointments

Honors and Awards

  • Gold Medal, Royal College of Anaesthetists (2013)
  • David M. Little Prize, Anesthesia History Association (2013)
  • Honorary Member, German Society of Anaesthesiology and Intensive Care Medicine (2013)
  • Sir Ivan Magill Inaugural Lecture, College of Anaesthetists of Ireland (2012)
  • Honorary Fellow, College of Anaesthetists of Ireland (2012)
  • Terry Davidson Plenary Lecture, Israel Society of Anesthesiologists (2011)
View All 17honors and awards of Steven Shafer

Boards, Advisory Committees, Professional Organizations

  • Chair, Anesthesia Advisory Panel on Sedasys, Ethicon Endo-Surgery (2003 - 2007)
  • Member, Committee on Drug Disposition, American Society of Anesthesiologists (1992 - 1999)
  • Chair, Committee on Drug Disposition, American Society of Anesthesiologists (2000 - 2005)
  • Member, NIGMS Pharmacological Sciences Review Committee (1993 - 1997)
  • Member, Department of Veterans Affairs Merit Review Committee for Alcoholism and Drug Dependence (1995 - 1999)
  • Member, FDA Anesthetic and Life Support Drugs Advisory Committee (2002 - 2004)
View All 18professional activities and affiliations of Steven Shafer

Professional Education

Residency: Hospital of the University of Pennsylvania PA (1986)
Medical Education: Stanford University School of Medicine CA (1983)
Fellowship: Stanford University School of Medicine CA (1987)
Board Certification: Anesthesia, American Board of Anesthesiology (1987)
Internship: Hospital of the University of Pennsylvania PA (1984)
Post-Doctoral: Stanford University, Clinical Pharmacology (1987)
View All 9

Courses

2013-14

Scientific Focus

Current Research and Scholarly Interests

Pharmacokinetics and pharmacodynamics of intravenous anesthetics, including drug interactions and continuous measures of drug effect; model-based drug development; target controlled drug delivery; advanced models of drug behavior.

Publications

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Publication Topics

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