Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Infectious Disease (2006)
- Fellowship: Stanford University Pediatric Infectious Disease Fellowship (2009) CA
- Residency: Beth Israel Deaconess Med Center/Harvard (2002) MA
- Medical Education: Sackler School of Medicine (1998) Israel
- Internship: Beth Israel Deaconess Med Center/Harvard (2000) MA
- MD, Sackler School of Medicine, Israel, Medicine (1999)
- BA, Sackler School of Medicine, Israel, Medical sciences (1994)
Honors & Awards
- American Liver Foundation Postdoctoral Fellowship Award, American Liver Foundation (ALF) (2006)
- Catalyst Award, Dr. Ralph & Marian Falk Medical Research Trust (2018)
- Chan Zuckerberg Biohub Investigator, Chan Zuckerberg Biohub (2022)
- Clinical Scientist Development Award, Doris Duke Charitable Foundation (2013)
- DDC Pilot/Feasibility Award, Stanford Digestive Disease Center (DDC) (2009)
- Dean's Fellowship Award, Stanford University School of Medicine, Stanford, CA (2004)
- Expansion award, Department of Defense (2021)
- IDSA 2009 Program Committee Choice Award, Infectious Diseases Society of America (IDSA) (2009)
- IDSA 2012 IDWeek Investigator Award, Infectious Diseases Society of America (IDSA) (2012)
- Interdisciplinary Initiative Program Award, Stanford Bio-X (2016)
- Investigator-Initiated Research Award, Department of Defense (2016)
- Investigator-Initiated Research Award, Department of Defense (2019)
- Investigator-Initiated Research Award, Department of Defense (2022)
- ITI Young Investigator Innovation Award, Stanford Institute for Immunity, Transplantation, and Infection (ITI) (2008)
- McCormick Faculty Award, Stanford University School of Medicine, Office of Diversity and Leadership (2015)
- Mentored Clinical Scientist Development Award (KO8), NIH/NIAID (2008 - 2013)
- Outstanding Thesis Award, Sackler School of Medicine, Tel-Aviv University (1999)
- Research Scholar Grant, American Cancer Society (2014)
- Stanford Bio-X Interdisciplinary Initiative Program Award, Stanford, Bio-X (2012)
- Transformation award, Dr. Ralph & Marian Falk Medical Research Trust (2020)
Memberships
- Investigator, Chan Zuckerberg Biohub (2022 - Present)
- Fellow (FIDSA), Infectious Diseases Society of America (2018 - Present)
- Faculty Fellow, Center for Innovation in Global Health (2016 - Present)
- Member, Bio-X Leadership Council (2016 - Present)
- Member, Stanford Biosafety committee (2016 - 2020)
Administrative Appointments
- Assistant Professor (UTL), Department of Medicine, Department of Microbiology and Immunology (2011 - 2018)
- Associate Professor, Department of Medicine, Department of Microbiology and Immunology (2018 - 2023)
- Infectious Diseases Fellowship, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine (2004 - 2008)
- Instructor of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine (2009 - 2011)
- Medical Internship and Residency, Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (1999 - 2002)
- Postdoctoral Fellowship. Supervisor: Dr. Jeffrey S. Glenn, Division of Gastroenterology and Hepatology, Stanford University School of Medicine (2003 - 2004)
- Professor (with tenure), Department of Medicine, Department of Microbiology and Immunology (2023 - Present)
- Research Studentship, Supervisor: Dr. Michael C. Carroll., Brigham and Women?s Hospital and the Center for Blood Research, Harvard Medical School, Boston, MA (1999 - 1999)
- Rotating internship (part of the M.D. requirements in Israel), Suraski Medical Center, Tel-Aviv, Israel (1997 - 1998)
Publications
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Complement C4 is protective for lupus disease independent of C3
Einav, S., Pozdnyakova, O. O., Ma, M. H., & Carroll, M. C. (2002). Complement C4 is protective for lupus disease independent of C3. JOURNAL OF IMMUNOLOGY, 168(3), 1036–1041. -
Immunopathogenesis of hepatitis C virus in the immunosuppressed host.
Einav, S., & Koziel, M. J. (2002). Immunopathogenesis of hepatitis C virus in the immunosuppressed host. Transplant Infectious Disease , 4(2), 85–92. -
Prenylation inhibitors: a novel class of antiviral agents
Einav, S., & Glenn, J. S. (2003). Prenylation inhibitors: a novel class of antiviral agents. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 52(6), 883–86. -
A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication
Einav, S., Elazar, M., Danieli, T., & Glenn, J. S. (2004). A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication. JOURNAL OF VIROLOGY, 78(20), 11288–95. -
TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication
Sklan, E. H., Serrano, R. L., Einav, S., Pfeffer, S. R., Lambright, D. G., & Glenn, J. S. (2007). TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(50), 36354–61. -
The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without ha-ras co-transfection
Einav, S., Sklan, E. H., Moon, H. M., Gehrig, E., Liu, P., Hao, Y., … Glenn, J. S. (2008). The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without ha-ras co-transfection. HEPATOLOGY, 47(3), 827–35. -
Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis
Einav, S., Gerber, D., Bryson, P. D., Sklan, E. H., Elazar, M., Maerkl, S. J., … Quake, S. R. (2008). Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. NATURE BIOTECHNOLOGY, 26(9), 1019–27. -
Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems
Parameswaran, P., Sklan, E., Wilkins, C., Burgon, T., Samuel, M. A., Lu, R., … Fire, A. Z. (2010). Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems. PLOS PATHOGENS, 6(2). -
A small molecule inhibits HCV replication and alters NS4B's subcellular distribution
Bryson, P. D., Cho, N.-J., Einav, S., Lee, C., Tai, V., Bechtel, J., … Glenn, J. S. (2010). A small molecule inhibits HCV replication and alters NS4B's subcellular distribution. ANTIVIRAL RESEARCH, 87(1), 1–8. -
The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors.
Einav, S., Sobol, H. D., Gehrig, E., & Glenn, J. S. (2010). The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. Journal of Infectious Diseases, 202(1), 65–74. -
Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly
Neveu, G., Barouch-Bentov, R., Ziv-Av, A., Gerber, D., Jacob, Y., & Einav, S. (2012). Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly. PLOS PATHOGENS, 8(8). -
Mechanisms of resistance to antiviral agents.
Mechanisms of resistance to antiviral agents. (2007). In Manual of Clinical Microbiology, 9th Edition, Murray PR Ed, Baron EJ Ed, Jorgensen JH Ed, Pfaller MA Ed, Tenover FC Ed, and Yolken RH Ed. American Society of Microbiology. -
B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins.
Ng, P. P., Kuo, C.-C., Wang, S., Einav, S., Arcaini, L., Paulli, M., … Levy, S. (2014). B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins. Blood, 123(10), 1512–15. -
Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents
Kovackova, S., Chang, L., Bekerman, E., Neveu, G., Barouch-Bentov, R., Chaikuad, A., … Herdewijn, P. (2015). Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents. JOURNAL OF MEDICINAL CHEMISTRY, 58(8), 3393–3410. -
AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets
Neveu, G., Ziv-Av, A., Barouch-Bentov, R., Berkerman, E., Mulholland, J., & Einav, S. (2015). AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets. JOURNAL OF VIROLOGY, 89(8), 4387–4404. -
Infectious disease. Combating emerging viral threats.
Bekerman, E., & Einav, S. (2015). Infectious disease. Combating emerging viral threats. Science , 348(6232), 282–83. -
Response—Applying antibiotics lessons to antivirals.
Bekerman, E., & Einav, S. (2015). Response—Applying antibiotics lessons to antivirals. Science , 348(6242), 1437-? -
Isothiazolo[4,3-b]pyridines as inhibitors of cyclin G associated kinase: synthesis, structure-activity relationship studies and antiviral activity
Li, J., Kovackova, S., Pu, S., Rozenski, J., De Jonghe, S., Einav, S., & Herdewijn, P. (2015). Isothiazolo[4,3-b]pyridines as inhibitors of cyclin G associated kinase: synthesis, structure-activity relationship studies and antiviral activity. MEDCHEMCOMM, 6(9), 1666–72. -
Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus
Plissonnier, M.-L., Lahlali, T., Michelet, M., Lebosse, F., Cottarel, J., Beer, M., … Parent, R. (2016). Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus. PLOS BIOLOGY, 14(3). -
Pathogen receptor discovery with a microfluidic human membrane protein array
Glick, Y., Ben-Ari, Y., Drayman, N., Pellach, M., Neveu, G., Boonyaratanakornkit, J., … Gerber, D. (2016). Pathogen receptor discovery with a microfluidic human membrane protein array. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(16), 4344–49. -
Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment.
Barouch-Bentov, R., Neveu, G., Xiao, F., Beer, M., Bekerman, E., Schor, S., … Einav, S. (2016). Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment. MBio, 7(6). -
The Hepatitis C Virus (HCV) NS4B RNA Binding Inhibitor Clemizole Is Highly Synergistic with HCV Protease Inhibitors
Einav, S., Dvory-Sobol, H., Gehrig, E., & Glenn, J. S. (2010). The Hepatitis C Virus (HCV) NS4B RNA Binding Inhibitor Clemizole Is Highly Synergistic with HCV Protease Inhibitors. JOURNAL OF INFECTIOUS DISEASES, 202(1), 65–74. -
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects
Bekerman, E., Neveu, G., Shulla, A., Brannan, J., Pu, S.-Y., Wang, S., … Einav, S. (2017). Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects. JOURNAL OF CLINICAL INVESTIGATION, 127(4), 1338–52. -
Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs.
Schor, S., & Einav, S. (2017). Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs. DNA Cell Biol., 63–69. -
Single-cell transcriptional dynamics of flavivirus infection.
Zanini, F., Pu, S.-Y. Y., Bekerman, E., Einav, S., & Quake, S. R. (2018). Single-cell transcriptional dynamics of flavivirus infection. ELife, 7. -
Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release.
Xiao, F., Wang, S., Barouch-Bentov, R., Neveu, G., Pu, S., Beer, M., … Einav, S. (2018). Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release. MBio, 9(2). -
Turning Up Your Nose for a Flaviviral Encephalitis Cure.
Barouch-Bentov, R., & Einav, S. (2018). Turning Up Your Nose for a Flaviviral Encephalitis Cure. Cell Host & Microbe, 23(4), 427–29. -
Combating Intracellular Pathogens with Repurposed Host-Targeted Drugs.
Schor, S., & Einav, S. (2018). Combating Intracellular Pathogens with Repurposed Host-Targeted Drugs. ACS Infectious Diseases, 4(2), 88–92. -
Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment (vol 47, e01456-16, 2016)
Barouch-Bentov, R., Neveu, G., Xiao, F., Beer, M., Bekerman, E., Schor, S., … Einav, S. (2018). Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment (vol 47, e01456-16, 2016). MBIO, 9(1). -
Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment.
Pu, S.-Y. Y., Xiao, F., Schor, S., Bekerman, E., Zanini, F., Barouch-Bentov, R., … Einav, S. (2018). Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment. Antiviral Research, 155, 67–75. -
Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.
Pu, S.-Y. Y., Wouters, R., Schor, S., Rozenski, J., Barouch-Bentov, R., Prugar, L. I., … Einav, S. (2018). Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity. Journal of Medicinal Chemistry. -
Viral journeys on the intracellular highways.
Robinson, M., Schor, S., Barouch-Bentov, R., & Einav, S. (2018). Viral journeys on the intracellular highways. Cellular and Molecular Life Sciences : CMLS. -
Virus-inclusive single-cell RNA sequencing reveals the molecular signature of progression to severe dengue.
Zanini, F., Robinson, M. L., Croote, D., Sahoo, M. K., Sanz, A. M., Ortiz-Lasso, E., … Einav, S. (2018). Virus-inclusive single-cell RNA sequencing reveals the molecular signature of progression to severe dengue. Proceedings of the National Academy of Sciences of the United States of America. -
Cyclin G-associated kinase (GAK) affinity and antiviral activity studies of a series of 3-C-substituted isothiazolo[4,3-b]pyridines.
Wouters, R., Pu, S.-Y., Froeyen, M., Lescrinier, E., Einav, S., Herdewijn, P., & De Jonghe, S. (2018). Cyclin G-associated kinase (GAK) affinity and antiviral activity studies of a series of 3-C-substituted isothiazolo[4,3-b]pyridines. European Journal of Medicinal Chemistry, 163, 256–65. -
A 20-Gene Set Predictive of Progression to Severe Dengue.
Robinson, M., Sweeney, T. E., Barouch-Bentov, R., Sahoo, M. K., Kalesinskas, L., Vallania, F., … Einav, S. (2019). A 20-Gene Set Predictive of Progression to Severe Dengue. Cell Reports, 26(5), 1104. -
MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.
Kumar, S., Barouch-Bentov, R., Xiao, F., Schor, S., Pu, S., Biquand, E., … Einav, S. (2019). MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Cell Reports, 26(7), 1800–1814.e5. -
Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs.
Schor, S., & Einav, S. (2018). Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs. DNA and Cell Biology, 37(2), 63–69. -
Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
Verdonck, S., Pu, S.-Y. Y., Sorrell, F. J., Elkins, J. M., Froeyen, M., Gao, L.-J. J., … De Jonghe, S. (2019). Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity. Journal of Medicinal Chemistry. -
Screening of Interactions with the ESCRT Machinery by a Gaussia princeps Split Luciferase-Based Complementation Assay.
Barouch-Bentov, R., Jacob, Y., & Einav, S. (2019). Screening of Interactions with the ESCRT Machinery by a Gaussia princeps Split Luciferase-Based Complementation Assay. Methods in Molecular Biology (Clifton, N.J.), 1998, 291–304. -
A 20-Gene Set Predictive of Progression to Severe Dengue
Robinson, M., Sweeney, T. E., Barouch-Bentov, R., Sahoo, M. K., Kalesinskas, L., Vallania, F., … Einav, S. (2019). A 20-Gene Set Predictive of Progression to Severe Dengue. CELL REPORTS, 26(5), 1104-+. -
Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase.
Martinez-Gualda, B., Pu, S.-Y., Froeyen, M., Herdewijn, P., Einav, S., & De Jonghe, S. (2019). Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase. Bioorganic & Medicinal Chemistry, 115188. -
Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics.
Durham, N. D., Agrawal, A., Waltari, E., Croote, D., Zanini, F., Fouch, M., … Goo, L. (2019). Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics. ELife, 8. -
Towards Predicting Progression to Severe Dengue.
Robinson, M., & Einav, S. (2020). Towards Predicting Progression to Severe Dengue. Trends in Microbiology. -
Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines.
Saul, S., Pu, S.-Y., Zuercher, W. J., Einav, S., & Asquith, C. R. (2020). Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines. Bioorganic & Medicinal Chemistry Letters, 30(16), 127284. -
Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-19.
Saul, S., & Einav, S. (2020). Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-19. ACS Infectious Diseases. -
BIKE regulates dengue virus infection and is a cellular target for broad-spectrum antivirals.
Pu, S., Schor, S., Karim, M., Saul, S., Robinson, M., Kumar, S., … Einav, S. (2020). BIKE regulates dengue virus infection and is a cellular target for broad-spectrum antivirals. Antiviral Research, 104966. -
Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.
Martinez-Gualda, B., Saul, S., Froeyen, M., Schols, D., Herdewijn, P., Einav, S., & De Jonghe, S. (2021). Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase. European Journal of Medicinal Chemistry, 213, 113158. -
The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection.
Yao, Z., Zanini, F., Kumar, S., Karim, M., Saul, S., Bhalla, N., … Einav, S. (2021). The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection. PLoS Neglected Tropical Diseases, 15(3), e0009306. -
Evaluation and identification of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV).
Saul, S., Huang, P.-T. T., Einav, S., & Asquith, C. R. (2021). Evaluation and identification of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV). Bioorganic & Medicinal Chemistry Letters, 128407. -
PIKfyve: a lipid kinase target for COVID-19, cancer and neurodegenerative disorders
Huang, P.-T., Einav, S., & Asquith, C. R. M. (2021). PIKfyve: a lipid kinase target for COVID-19, cancer and neurodegenerative disorders. NATURE REVIEWS DRUG DISCOVERY, 20(10), 730. -
Optimization of 4-Anilinoquinolines as Dengue Virus Inhibitors.
Huang, P.-T., Saul, S., Einav, S., & Asquith, C. R. (2021). Optimization of 4-Anilinoquinolines as Dengue Virus Inhibitors. Molecules (Basel, Switzerland), 26(23). -
An 8-gene machine learning model improves clinical prediction of severe dengue progression.
Liu, Y. E., Saul, S., Rao, A. M., Robinson, M. L., Agudelo Rojas, O. L., Sanz, A. M., … Khatri, P. (2022). An 8-gene machine learning model improves clinical prediction of severe dengue progression. Genome Medicine, 14(1), 33. -
The cargo adaptor protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection.
Schor, S., Pu, S., Nicolaescu, V., Azari, S., Koivomagi, M., Karim, M., … Einav, S. (2022). The cargo adaptor protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection. The Journal of Biological Chemistry, 101956. -
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies.
Karim, M., Saul, S., Ghita, L., Sahoo, M. K., Ye, C., Bhalla, N., … Einav, S. (2022). Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies. Antiviral Research, 105367. -
Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX.
Shirasaki, T., Feng, H., Duyvesteyn, H. M., Fusco, W. G., McKnight, K. L., Xie, L., … Lemon, S. M. (2022). Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX. PLoS Pathogens, 18(8), e1010543. -
Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents.
Martinez-Gualda, B., Graus, M., Camps, A., Vanhulle, E., Saul, S., Azari, S., … De Jonghe, S. (2022). Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents. Frontiers in Chemistry, 10, 1058229. -
Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics.
Robinson, M. L., Glass, D. R., Duran, V., Agudelo Rojas, O. L., Sanz, A. M., Consuegra, M., … Einav, S. (2023). Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics. Science Advances, 9(12), eade7702. -
Preparing for the next viral threat with broad-spectrum antivirals.
Karim, M., Lo, C.-W. W., & Einav, S. (2023). Preparing for the next viral threat with broad-spectrum antivirals. The Journal of Clinical Investigation, 133(11). -
Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects.
Saul, S., Karim, M., Ghita, L., Huang, P.-T. T., Chiu, W., Durán, V., … Einav, S. (2023). Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects. The Journal of Clinical Investigation. -
Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses.
Lubow, J., Levoir, L. M., Ralph, D. K., Belmont, L., Contreras, M., Cartwright-Acar, C. H., … Goo, L. (2023). Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses. PLoS Pathogens, 19(10), e1011722. -
Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach.
Ghita, L., Yao, Z., Xie, Y., Duran, V., Cagirici, H. B., Samir, J., … Einav, S. (2023). Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach. Nature Immunology. -
Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans.
Ratnasiri, K., Zheng, H., Toh, J., Yao, Z., Duran, V., Donato, M., … Khatri, P. (2024). Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans. Cell Reports, 43(2), 113706. -
Chemical inactivation strategies for SARS-CoV-2-infected cells and organoids.
Karim, M., Pohane, A. A., Lo, C.-W. W., Einav, S., & Garhyan, J. (2024). Chemical inactivation strategies for SARS-CoV-2-infected cells and organoids. STAR Protocols, 5(1), 102906. -
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
Gerninghaus, J., Zhubi, R., Krämer, A., Karim, M., Tran, D. H., Joerger, A. C., … Hanke, T. (2024). Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity. BioRxiv : the Preprint Server for Biology. -
An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.
Westberg, M., Su, Y., Zou, X., Huang, P., Rustagi, A., Garhyan, J., … Lin, M. Z. (2024). An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations. Science Translational Medicine, 16(738), eadi0979.
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