Biography
Professional Summary
Education & Certifications
- Board Certification: American Board of Psychiatry and Neurology, Neurology (1998)
- Residency: University of California at San Francisco School of Medicine (1995) CA
- Internship: University of California at San Francisco School of Medicine (1992) CA
- MD, Emory University, Medicine (1991)
- BA, Yale University, Molecular Biophysics and Biochemistry (1985)
Honors & Awards
- Basil O'Connor Award, March of Dimes (2003-05)
- Brain and Immuno imaging Grant, Dana Foundation (2007-09)
Publications
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Organic anion transport is the primary function of the SLC17/type I phosphate transporter family
Reimer, R. J., & Edwards, R. H. (2004). Organic anion transport is the primary function of the SLC17/type I phosphate transporter family. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 447(5), 629–35. -
Varied mechanisms underlie the free sialic acid storage disorders
Wreden, C. C., Wlizla, M., & Reimer, R. J. (2005). Varied mechanisms underlie the free sialic acid storage disorders. JOURNAL OF BIOLOGICAL CHEMISTRY, 280(2), 1408–16. -
Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors
Okumoto, S., Looger, L. L., Micheva, K. D., Reimer, R. J., Smith, S. J., & Frommer, W. B. (2005). Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(24), 8740–45. -
Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy
Tani, H., Bandrowski, A. E., Parada, I., Wynn, M., Huguenard, J. R., Prince, D. A., & Reimer, R. J. (2007). Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy. NEUROBIOLOGY OF DISEASE, 25(2), 230–38. -
Biochemical and genetic analysis of ANK in arthritis and bone disease
Gurley, K. A., Reimer, R. J., & Kingsley, D. M. (2006). Biochemical and genetic analysis of ANK in arthritis and bone disease. AMERICAN JOURNAL OF HUMAN GENETICS, 79(6), 1017–29. -
G328E and G409E sialin missense mutations similarly impair transport activity, but differentially affect trafficking
Myall, N. J., Wreden, C. C., Wlizla, M., & Reimer, R. J. (2007). G328E and G409E sialin missense mutations similarly impair transport activity, but differentially affect trafficking. MOLECULAR GENETICS AND METABOLISM, 92(4), 371–74. -
Imaging of glutamate in brain slices using FRET sensors
Dulla, C., Tani, H., Okumoto, S., Frommer, W. B., Reimer, R. J., & Fluguenard, J. R. (2008). Imaging of glutamate in brain slices using FRET sensors. JOURNAL OF NEUROSCIENCE METHODS, 168(2), 306–19. -
Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport
Zaia, K. A., & Reimer, R. J. (2009). Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(13), 8439–48. -
The Lysosomal Sialic Acid Transporter Sialin Is Required for Normal CNS Myelination
Prolo, L. M., Vogel, H., & Reimer, R. J. (2009). The Lysosomal Sialic Acid Transporter Sialin Is Required for Normal CNS Myelination. JOURNAL OF NEUROSCIENCE, 29(49), 15355–65. -
Glutamine Is Required for Persistent Epileptiform Activity in the Disinhibited Neocortical Brain Slice
Tani, H., Dulla, C. G., Huguenard, J. R., & Reimer, R. J. (2010). Glutamine Is Required for Persistent Epileptiform Activity in the Disinhibited Neocortical Brain Slice. JOURNAL OF NEUROSCIENCE, 30(4), 1288–1300. -
Structure-Function Studies of the SLC17 Transporter Sialin Identify Crucial Residues and Substrate-induced Conformational Changes
Courville, P., Quick, M., & Reimer, R. J. (2010). Structure-Function Studies of the SLC17 Transporter Sialin Identify Crucial Residues and Substrate-induced Conformational Changes. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(25), 19316–23. -
Biochemistry to the Rescue: A CIC-2 Auxiliary Subunit Provides a Tangible Link to Leukodystrophy
Maduke, M. C., & Reimer, R. J. (2012). Biochemistry to the Rescue: A CIC-2 Auxiliary Subunit Provides a Tangible Link to Leukodystrophy. NEURON, 73(5), 855–57. -
Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation.
Dulla, C. G., Tani, H., Brill, J., Reimer, R. J., & Huguenard, J. R. (2012). Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation. Neurobiology of Disease, 49C, 232–246. -
SLC17: a functionally diverse family of organic anion transporters.
Reimer, R. J. (2013). SLC17: a functionally diverse family of organic anion transporters. Molecular Aspects of Medicine, 34(2-3), 350–59. -
Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation
Dulla, C. G., Tani, H., Brill, J., Reimer, R. J., & Huguenard, J. R. (2013). Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation. NEUROBIOLOGY OF DISEASE, 49, 232–246. -
Vesicular uptake and exocytosis of L-aspartate is independent of sialin
Morland, C., Nordengen, K., Larsson, M., Prolo, L. M., Farzampour, Z., Reimer, R. J., & Gundersen, V. (2013). Vesicular uptake and exocytosis of L-aspartate is independent of sialin. FASEB JOURNAL, 27(3), 1264–1274. -
Membrane topology of the Drosophila vesicular glutamate transporter
Fei, H., Karnezis, T., Reimer, R. J., & Krantz, D. E. (2007). Membrane topology of the Drosophila vesicular glutamate transporter. JOURNAL OF NEUROCHEMISTRY, 101(6), 1662–1671. -
A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release.
Tani, H., Dulla, C. G., Farzampour, Z., Taylor-Weiner, A., Huguenard, J. R., & Reimer, R. J. (2014). A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release. Neuron, 81(4), 888–900. -
alpha 5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth
Sengupta, S., Weeraratne, S. D., Sun, H., Phallen, J., Rallapalli, S. K., Teider, N., … Cho, Y.-J. (2014). alpha 5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. ACTA NEUROPATHOLOGICA, 127(4), 593–603. -
Endozepines.
Farzampour, Z., Reimer, R. J., & Huguenard, J. (2015). Endozepines. Advances in Pharmacology (San Diego, Calif.), 72, 147–64. -
Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1
Wagh, D., Terry-Lorenzo, R., Waites, C. L., Leal-Ortiz, S. A., Maas, C., Reimer, R. J., & Garner, C. C. (2015). Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1. PLOS ONE, 10(4). -
Plasma taurine levels are not affected by vigabatrin in pediatric patients.
Spelbrink, E. M., Mabud, T. S., Reimer, R., & Porter, B. E. (2016). Plasma taurine levels are not affected by vigabatrin in pediatric patients. Epilepsia, 57(8), e168–72. -
Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon
Terry-Lorenzo, R. T., Torres, V. I., Wagh, D., Galaz, J., Swanson, S. K., Florens, L., … Garner, C. C. (2016). Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon. PLOS ONE, 11(12). -
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund, N. D., Schneider, K., Leal-Ortiz, S., Montenegro-Venegas, C., Kim, S. A., Garner, L. C., … Garner, C. C. (2017). Bassoon Controls Presynaptic Autophagy through Atg5. Neuron, 93(4), 897–913 e7. -
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
Sloan, S. A., Darmanis, S., Huber, N., Khan, T. A., Birey, F., Caneda, C., … Pasca, S. P. (2017). Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells. Neuron, 95(4), 779–90.e6. -
Analysis of glutamate recycling in maintenance of epileptiform activity the acute slice
Reimer, R. J., Tani, H., Dulla, C. G., & Huguenard, J. R. (2007). Analysis of glutamate recycling in maintenance of epileptiform activity the acute slice. EPILEPSIA, 48, 240. -
GLUTAMINE POTENTIATES GLUTAMATE RELEASE DURING HIGH FREQUENCY STIMULATION OF ISOLATED LAYER 1 AXONS
Reimer, R. J., Tani, H., Dula, C., & Huguenard, J. (2009). GLUTAMINE POTENTIATES GLUTAMATE RELEASE DURING HIGH FREQUENCY STIMULATION OF ISOLATED LAYER 1 AXONS. EPILEPSIA, 50, 479–80. -
Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate
Johnson, J., Tian, N., Caywood, M. S., Reimer, R. J., Edwards, R. H., & Copenhagen, D. R. (2003). Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate. JOURNAL OF NEUROSCIENCE, 23(2), 518–29. -
Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion.
Prolo, L. M., Li, A., Owen, S. F., Parker, J. J., Foshay, K., Nitta, R. T., … Grant, G. A. (2019). Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion. Scientific Reports, 9(1), 14020. -
NEUROMUSCULAR RESPIRATORY FAILURE IN THE ICU: AN "UNWEANABLE" PATIENT AND A NOVEL TIERED PROTOCOL
Murray, N., Reimer, R., & Cao, M. (2020). NEUROMUSCULAR RESPIRATORY FAILURE IN THE ICU: AN "UNWEANABLE" PATIENT AND A NOVEL TIERED PROTOCOL. CRITICAL CARE MEDICINE, 48. -
Air pollution, methane super-emitters, and oil and gas wells in Northern California: the relationship with migraine headache prevalence and exacerbation.
Elser, H., Morello-Frosch, R., Jacobson, A., Pressman, A., Kioumourtzoglou, M.-A., Reimer, R., & Casey, J. A. (2021). Air pollution, methane super-emitters, and oil and gas wells in Northern California: the relationship with migraine headache prevalence and exacerbation. Environmental Health : a Global Access Science Source, 20(1), 45. -
Mini-Review Free Sialic Acid Storage Disorder: Progress and Promise.
Huizing, M., Hackbarth, M. E., Adams, D. R., Wasserstein, M., Patterson, M. C., Walkley, S. U., … Zoncu, R. (2021). Mini-Review Free Sialic Acid Storage Disorder: Progress and Promise. Neuroscience Letters, 135896. -
Correction to: Air pollution, methane super-emitters, and oil and gas wells in Northern California: the relationship with migraine headache prevalence and exacerbation.
Elser, H., Morello-Frosch, R., Jacobson, A., Pressman, A., Kioumourtzoglou, M.-A., Reimer, R., & Casey, J. A. (2021). Correction to: Air pollution, methane super-emitters, and oil and gas wells in Northern California: the relationship with migraine headache prevalence and exacerbation. Environmental Health : a Global Access Science Source, 20(1), 57. -
Leigh Disease-Like Neuropathology in an Adult Following Covid-19 Infection and Global Anoxia
Sobel, R., Dulken, B., Reimer, R., & Louie, C. (2021). Leigh Disease-Like Neuropathology in an Adult Following Covid-19 Infection and Global Anoxia. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. OXFORD UNIV PRESS INC. -
Acute on Chronic Neuromuscular Respiratory Failure in the Intensive Care Unit: Optimization of Triage, Ventilation Modes, and Extubation
Murray, N. M., Reimer, R. J., & Cao, M. (2021). Acute on Chronic Neuromuscular Respiratory Failure in the Intensive Care Unit: Optimization of Triage, Ventilation Modes, and Extubation. CUREUS, 13(7). -
Acute on Chronic Neuromuscular Respiratory Failure in the Intensive Care Unit: Optimization of Triage, Ventilation Modes, and Extubation.
Murray, N. M., Reimer, R. J., & Cao, M. (2021). Acute on Chronic Neuromuscular Respiratory Failure in the Intensive Care Unit: Optimization of Triage, Ventilation Modes, and Extubation. Cureus, 13(7), e16297. -
Air pollution, methane super-emitters, and oil and gas wells in Northern California: the relationship with migraine headache prevalence and exacerbation
Elser, H., Morello-Frosch, R., Jacobson, A., Pressman, A., Kioumourtzoglou, M.-A., Reimer, R., & Casey, J. (2021). Air pollution, methane super-emitters, and oil and gas wells in Northern California: the relationship with migraine headache prevalence and exacerbation. NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Metalworking Fluid Exposure and Stroke Mortality Among U.S. Autoworkers.
Elser, H., Chen, K. T., Arteaga, D., Reimer, R., Picciotto, S., Costello, S., & Eisen, E. A. (1800). Metalworking Fluid Exposure and Stroke Mortality Among U.S. Autoworkers. American Journal of Epidemiology. -
Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit.
Vaughen, J. P., Theisen, E., Rivas-Serna, I. M., Berger, A. B., Kalakuntla, P., Anreiter, I., … Clandinin, T. R. (2022). Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit. Neuron. -
An electronic health record cohort of Veterans with amyotrophic lateral sclerosis.
Reimer, R. J., Goncalves, A., Soper, B., Cadena, J., Wilson, J. L., Gryshuk, A. L., … Ray, P. (2023). An electronic health record cohort of Veterans with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 1–7. -
A concerted action to explore therapies for free sialic acid storage disease
Huizing, M., Walkley, S. U., Wasserstein, M., Anne-Longin, C., Wang, R. Y., Reimer, R., … Gahl, W. A. (2023). A concerted action to explore therapies for free sialic acid storage disease. MOLECULAR GENETICS AND METABOLISM. ACADEMIC PRESS INC ELSEVIER SCIENCE. -
Collaborative research efforts drive therapeutic advancements for free sialic acid storage disorder (FSASD)
Malicdan, M. C., Adams, D. R., Brooks, P. J., Dobrenis, K., Gahl, W. A., Gasnier, B., … Huizing, M. (2024). Collaborative research efforts drive therapeutic advancements for free sialic acid storage disorder (FSASD). MOLECULAR GENETICS AND METABOLISM. ACADEMIC PRESS INC ELSEVIER SCIENCE.
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