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Richard J. Reimer, MD

Academic Appointments

  • Associate Professor of Neurology and, by courtesy, of Molecular and Cellular Physiology at the Palo Alto Veterans Administration Health Care System

Key Documents

Contact Information

  • Clinical Offices
    Neurology Clinic 300 Pasteur Dr A301 MC 5325 Stanford, CA 94305
    Tel Work (650) 723-6469 Fax (650) 498-6326
  • Academic Offices
    Personal Information
    Email
    Not for medical emergencies or patient use

Professional Overview

Clinical Focus

  • Neurology

Academic Appointments

Honors and Awards

  • Brain and Immuno imaging Grant, Dana Foundation (2007-09)
  • Basil O'Connor Award, March of Dimes (2003-05)

Professional Education

Residency: UCSF School of Medicine CA (1995)
Board Certification: Neurology, American Board of Psychiatry and Neurology (1998)
Internship: UCSF School of Medicine CA (1992)
Medical Education: Emory University Hospital GA (1991)
Residency: UCSF, Neurology (1995)
MD: Emory University, Medicine (1991)
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Postdoctoral Advisees

Shaoyun Zang

Scientific Focus

Current Research and Scholarly Interests

Reimer Lab interests

A primary interest of our lab is to understand how nerve cells make and recycle neurotransmitters, the small molecules that they use to communicate with each other. In better defining these processes we hope to achieve our long-term goal of identifying novel sites for treatment of diseases such as epilepsy and Parkinson Disease. In our studies on neurotransmitter metabolism we have focused our efforts on transporters, a functional class of proteins that move neurotransmitters and other small molecules across membranes in cells. Transporters have many characteristics that make them excellent pharmacological targets, and not surprisingly some of the most effective treatments for neuropsychiatric disorders are directed at transporters. We are specifically focusing on two groups of transporters – vesicular neurotransmitter transporters that package neurotransmitters into vesicles for release, and glutamine transporters that shuttle glutamine, a precursor for two major neurotransmitters glutamate and GABA, to neurons from glia, the supporting cells that surround them. We are pursuing these goals through molecular and biochemical studies, and, in collaboration with the Huguenard and Prince labs, through physiological and biosensor based imaging studies to better understand how pharmacological targeting of these molecules will influence neurological disorders.

A second interest of our lab is to define mechanism underlying the pathology of lysosomal storage disorders. Lysosomes are membrane bound acidic intracellular organelles filled with hydrolytic enzymes that normally function as recycling centers within cells by breaking down damaged cellular macromolecules. Several degenerative diseases designated as lysosomal storage disorders (LSDs) are associated with the accumulation of material within lysosomes. Tay-Sachs disease, Neimann-Pick disease and Gaucher disease are some of the more common LSDs. For reasons that remain incompletely understood, these diseases often affect the nervous system out of proportion to other organs. As a model for LSDs we are studying the lysosomal free sialic acid storage disorders. These diseases are the result of a defect in transport of sialic acid across lysosomal membranes and are associated with mutations in the gene encoding the sialic acid transporter sialin. We are using molecular, genetic and biochemical approaches to better define the normal function of sialin and to determine how loss of sialin function leads to neurodevelopmental defects and neurodegeneration associated with the lysosomal free sialic acid storage disorders.

Publications

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Publication Topics

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