Clinical Focus

• Allergy and Immunology
• Pediatric Allergy/Immun

Administrative Appointments

• Associate Professor, Affiliate appointment in Otolaryngology (2011 - present)
• Associate Professor, Pediatrics (2011 - present)
• Faculty Member, Multidisciplinary Program in Immunology (2007 - present)
• Faculty Member, Stanford Institute of Immunity, Transplantation and Infectious Disease (2007 - present)
• Assistant Professor, Pediatrics (2007 - 2011)

Honors and Awards

• Junior Faculty Award, Clinical Immunological Society (2010)
• National Junior Faculty Award, American Lung Association (2009)
• Fellow, American Academy of Asthma, Allergy and Immunology (2008-present)
• Speaker Award, La Entrada Inspirational Speaker Series (2007)
• National Junior Faculty Award, American Academy of Asthma, Allergy and Immunology (2007)

Professional Education

Postdoctoral Advisees

Takahiro Kanai,  Minou Le-Carlson,  Laurent Reber

Graduate & Fellowship Program Affiliations

• Immunology
• Pediatrics

Community and International Work

• Volunteer Clinical Faculty, Menlo Park VA 

Internet Links

• The Nadeau Lab

Current Research Interests

The Nadeau Laboratory focuses on the mechanisms of immune dysfunction in primary immune disease (PID), allergy, and asthma. In recent years, allergic disorders have reached epidemic proportions in children and adults. Many studies have determined that the immune system of patients with allergies (also called atopy), such as asthma, atopic dermatitis, food allergies, allergic rhinitis, allergic conjunctivitis and other atopic disorders, is overactive and skewed toward a certain subtype of immune cell called the Th2 cell. So far, there is little understanding of how cells turn off this abnormal proliferation and activation of the Th2 cell.

The Nadeau Laboratory has found that a type of cell, called the natural regulatory T cells (nTreg), can decrease Th2 cell overactivation in allergies, thus leading to improvement or even reversal of the allergic condition. By understanding how these Treg cells work, we hope to discover new diagnostic and therapeutic ways to treat or prevent allergic conditions.

The Nadeau Laboratory maintains a database and sample/tissue bank of healthy controls and patients treated at LPCH/Stanford Medical Center with allergic disorders. The main focus of our laboratory is five-fold:

1. To determine the role of STAT5a and STAT5b in Treg development and function;
2. Since Tregs may respond to pollution, we are studying the effect of ambient air pollution on Tregs;
3. Since most allergic conditions start in childhood, we are examining the role of Th2 and Treg in different age groups with and without allergies;
4. Since the activity of Th2 and Treg is determined by their interactions with other cell types, such as epithelial cells and dendritic cells, we are studying their effects on Th2/Treg interactions; and
5. Since improvement of Treg function is associated with improvement of allergic conditions, we are designing new allergy treatments (for example, sublingual immunotherapy, small molecule chemokines) that enhance Treg function.

Clinical Trials

• Understanding Allergies Recruiting
• Understanding and Diagnosing Allergic Disease in Twins Recruiting
• Sublingual Immunotherapy (SLIT) No longer recruiting
• Use of Symbicort or Pulmicort to treat viral-mediated asthma exacerbations Completed
• Xolair Treatment for Milk Allergic Children Completed

Publications

• Oral Immunotherapy and Anti-IgE Antibody-Adjunctive Treatment for Food Allergy. Nadeau KC, Kohli A, Iyengar S, Dekruyff RH, Umetsu DT. Immunol Allergy Clin North Am. 2012; 32 (1): 111-33
• Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Gernez Y, Tirouvanziam R, Yu G, Ghosn EE, Reshamwala N, Nguyen T, Tsai M, Galli SJ, Herzenberg LA, Herzenberg LA, Nadeau KC. Int Arch Allergy Immunol. 2011; 154 (4): 318-27
• Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID. Yu GP, Nadeau KC, Berk DR, de Saint Basile G, Lambert N, Knapnougel P, Roberts J, Kavanau K, Dunn E, Stiehm ER, Lewis DB, Umetsu DT, Puck JM, Cowan MJ. Pediatr Transplant. 2011; 15 (7): 733-41
• Immunophenotyping of peripheral eosinophils demonstrates activation in eosinophilic esophagitis. Nguyen T, Gernez Y, Fuentebella J, Patel A, Tirouvanziam R, Reshamwala N, Bass D, Berquist WE, Cox KL, Kerner JA, Nadeau KC. J Pediatr Gastroenterol Nutr. 2011; 53 (1): 40-7
• Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. Nadeau KC, Schneider LC, Hoyte L, Borras I, Umetsu DT. J Allergy Clin Immunol. 2011; 127 (6): 1622-4