Joy Wu
Academic Appointments
- Assistant Professor, Medicine - Endocrinology, Gerontology, & Metabolism
Key Documents
Contact Information
-
Clinical Offices
Endocrinology Clinic 300 Pasteur Dr A175 MC 5303 Stanford, CA 94305 Tel Work (650) 723-6961 Fax (650) 725-8418
- Academic Offices
Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Osteoporosis
- Metabolic Bone Disease
- Endocrinology
- Diabetes andMetabolism
Honors and Awards
- NIH Director's New Innovator Award, NIH (2011 - 2016)
- Clinical Scientist Program Instructor Development Award, Harvard Stem Cell Institute (2009 - 2011)
- Claflin Distinguished Scholar Award, Massachusetts General Hospital (2009 - 2011)
- John Haddad Young Investigator Award, Advances in Mineral Metabolism (2008)
- Merck Senior Fellow Award, The Endocrine Society (2007)
- Young Investigator Award, American Society for Bone and Mineral Research Annual Meeting (2006)
Professional Education
| Board Certification: | Endocrinology, Diabetes andMetabolism, American Board of Internal Medicine (2006) |
| Fellowship: | Massachusetts General Hospital MA (2006) |
| Board Certification: | Internal Medicine, American Board of Internal Medicine (2004) |
| Residency: | Brigham & Woman's Hospital (2003) |
| Medical Education: | Duke University School of Medicine NC (2001) |
| Board Certification: | Endocrinology, Diabetes and Metabolism, ABIM (2006) |
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
As a physician scientist with a clinical focus on osteoporosis, my laboratory focuses on the mechanisms guiding the differentiation of mesenchymal stem cells, and how mesenchymal lineages support hematopoiesis in the bone marrow. In particular we are interested in the pathways that regulate the differentiation of mesenchymal progenitors into osteoblast and adipocyte lineages, using genetically modified mice and lineage tracing techniques in vivo. We are also studying the role of the osteoblast niche in supporting hematopoietic stem cell and B lymphocyte development, in both animal models as well as translational studies in humans. Finally, my laboratory is using induced pluripotent stem cells to study osteoblast differentiation in a skeletal complementation model in vivo.
Publications
- Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling. Blood. 2013; (6): 930-9
- Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice. J Clin Invest. 2011; (9): 3492-504
- Potent constitutive cyclic AMP-generating activity of XLαs implicates this imprinted GNAS product in the pathogenesis of McCune-Albright syndrome and fibrous dysplasia of bone. Bone. 2011; (2): 312-20
- Role of the osteoblast lineage in the bone marrow hematopoietic niches. J Bone Miner Res. 2009; (5): 759-64
- Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A. 2008; (44): 16976-81
- Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin. Mol Cell Biol. 2001; (17): 6066-70
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