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Joshua W. Knowles

Academic Appointments

Key Documents

Contact Information

  • Academic Offices
    Personal Information
    Email Tel (650) 723-1431
    Not for medical emergencies or patient use

Professional Overview

Clinical Focus

  • Cardiology
  • Insulin Resistance
  • Familial Hypercholesterolemia
  • Cardiomyopathy, Hypertrophic
  • Cardiovascular Disease

Academic Appointments

Administrative Appointments

  • Chief Medical Officer, The FH Foundation (2012 - present)

Honors and Awards

  • National Fellow to Faculty Transition Award, AHA (7/1/10-7/1/15)
  • Fellow, ACC (2012)
  • Fellow, AHA (2012)
  • Diplomate, National Lipid Association (2012)
  • Alderman Award for Excellence in Clinical Research, Stanford Cardiovascular Medicine (2008, 2009)
  • Fellowship Award, Future Leaders in CV Medicine (2006)
View All 7honors and awards of Joshua Knowles

Boards, Advisory Committees, Professional Organizations

  • Board Member, The FH Foundation (2012 - present)

Professional Education

Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2010)
Fellowship: Stanford Hospital and Clinics CA (2010)
Residency: Stanford Hospital and Clinics CA (2005)
Medical Education: University of North Carolina - Chapel Hill NC (2003)
PhD: University of North Carolina, Chapel Hill, Genetics and Molecular Biology (2001)
Board Certification: Internal Medicine, American Board of Internal Medicine (2006)

Community and International Work

Scientific Focus

Current Research and Scholarly Interests

The overall theme of my work is to understand the genetic basis of complex cardiovascular diseases such as coronary disease and insulin resistance. Currently, I am involved in genome wide association (GWA) studies of coronary disease through the NIH-funded ADVANCE study and of insulin resistance through the international GENESIS project. After using the GWA approach to discover and validate interesting candidate genes, I hope to explore the biology underlying these genes and pathways using cell culture and in vivo model systems. I am also using iPSC technology (induced pluripotent stem cells) to develop model systems for the study of insulin resistance through the NIH-funded GENESiPS project.

I also have a strong interest in developing tools to help translate newly emerging genetic data into clinical practice and am currently the PI of a randomized trial where we are examining whether we can improve patient coronary disease risk factor profiles by giving them information about their inherited risk of coronary disease.

Clinically, I am interested in the care of patients with inherited cardiovascular conditions. In particular I am focused on individuals with Familial Hypercholesterolemia. I also have an interest in treating Hypertrophic Cardiomyopathy. I take care of these patients in the Stanford Center for Inherited Cardiovascular Disease.

Clinical Trials

Publications

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Publication Topics

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