Eric Sibley, M.D., Ph.D.
Academic Appointments
- Associate Professor, Pediatrics - Gastroenterology
- Member, Child Health Research Institute
Key Documents
Contact Information
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Clinical Offices
Pediatric Gastroenterology 730 Welch Rd, 2nd Floor Palo Alto, CA 94304 Tel Work (650) 721-2250 Fax (650) 498-5608Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information Email Tel (650) 723-5070Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Gastroenterology/Nutrition/Hepatology, Pediatric
- Pediatric Gastroenterology
Administrative Appointments
- Chair/Vice-Chair, Growth, Development and Aging Section, American Gastroenterology Association (2007 - 2011)
- Editor-In-Chief, Journal of Pediatric Gastroenterology and Nutrition (2006 - 2010)
- Senator, School of Medicine Faculty Senate (2009 - 2013)
- Associate Director (Research), Stanford Pediatric Gastroenterology Training Program (2004 - present)
- Member, Clinical and Integrative Gastrointestinal Pathobiology Study Section, NIH (2004 - 2007)
- Admissions Committee, Stanford University School of Medicine (1998 - 2001)
Honors and Awards
- Member, ACCA (2010-present)
- Council, elected, American Gastroenterology Association (2007-2011)
- Council, elected, Society for Pediatric Research (2005-2008)
- Named Investigator Award, Stanford Digestive Disease Center (2002-2003)
- Young Faculty Investigator Award, North American Society for Pediatric Gastroenterology and Nutrition (1998)
Professional Education
| Residency: | Harbor-UCLA Medical Center CA (1993) |
| Board Certification: | Pediatric Gastroenterology, American Board of Pediatrics (1997) |
| Fellowship: | Stanford University School of Medicine CA (1996) |
| Undergraduate Education: | Harvard College, A.B., Biochemical Sciences (1982) |
| Medical Education: | Johns Hopkins University School of Medicine MD (1990) |
| Graduate Education: | The Johns Hopkins University,, Ph.D., Biological Chemistry (1990) |
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
Transcriptional Regulation of Intestine-Specific Gene Expression during Gut Development and Maturation.
The mammalian gastrointestinal tract matures from a primitive tube into morphologically and functionally distinct regions during development. The mature small intestine functions in the digestion and absorption of ingested nutrients. Expression of several nutrient hydrolases is spatially restricted to distinct segments along the cephalo-caudal axis of the small intestine and is temporally regulated during postnatal maturation. Intestinal lactase, the hydrolase responsible for the digestion of lactose in milk, is expressed at highest levels in the jejunal segment of the small intestine shortly after birth and then declines dramatically just prior to weaning in most mammals.
Our research is directed towards defining the mechanisms regulating the spatial and temporal restriction of lactase gene expression during intestinal development. The normal maturational decline in lactase enzymatic activity is correlated with a decline in lactase messenger RNA levels and is transcriptionally regulated. We are currently identifying maturation-specific lactase gene cis elements and characterizing the nuclear proteins interacting with those elements in cell culture and transgenic animals. We seek to define the interactions of the lactase gene elements and nuclear factors involved in mediating transcriptional control. The overall goal is to relate these lactase control mechanisms to the broader pathways specifying acquisition of a small intestinal phenotype. We are also investigating gene transfer methods to deliver specific genes to the intestine.
Publications
- Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice. Am J Physiol Gastrointest Liver Physiol. 2012; (4): G407-19
- Intestinal Pdx1 mediates nutrient metabolism gene networks and maternal expression is essential for perinatal growth in mice. Biochem Biophys Res Commun. 2012; (3): 549-53
- PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells. Biochem Biophys Res Commun. 2012; (1): 183-7
- The human lactase persistence-associated SNP -13910*T enables in vivo functional persistence of lactase promoter-reporter transgene expression. Hum Genet. 2012; (7): 1153-9
- 13915*G DNA polymorphism associated with lactase persistence in Africa interacts with Oct-1. Hum Genet. 2011; (1): 111-3
- The Western transition. J Pediatr Gastroenterol Nutr. 2011; (1): 2
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