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David Fiorentino, MD, PhD

Academic Appointments

  • Associate Professor of Dermatology and, by courtesy, of Medicine (Immunology and Rheumatology) at the Stanford University Medical Center

Contact Information

  • Clinical Offices
    Medical Dermatology 450 Broadway St Pavillion B FL 4 MC 5338 Redwood City, CA 94063
    Tel Work (650) 723-6316 Fax (650) 721-3476
  • Academic Offices
    Administrative Contact
    Olena Mykhaylichenko Administrative Associate Tel Work 650-721-7193
    Not for medical emergencies or patient use

Professional Overview

Clinical Focus

  • Dermatology
  • Autoimmune Diseases

Academic Appointments

Administrative Appointments

  • Founding member, North American Rheumatologic Dermatology Society (NARDS) (2006 - present)
  • Scientific advisory board, National Psoriasis Foundation (2008 - present)
  • Advisory board, The Myositis Association (2008 - present)
  • Advisory board, Lupus Foundation of America (2008 - present)
  • Steering Committee, Group for Research and Assessment in Psoriasis and Psoriatic Arthritis (GRAPPA) (2006 - present)
  • Editorial Board, Journal of The American Academy of Dermatology (2004 - present)

Honors and Awards

  • Clinical Immunology Faculty Scholarship Award, Center for Clinical Immunology at Stanford (2003-2006)
  • Medical Dermatology Development Award, Dermatology Foundation (2004-2007)

Professional Education

Medical Education: Stanford University School of Medicine CA (1998)
Residency: Stanford University School of Medicine CA (2002)
Board Certification: Dermatology, American Board of Dermatology (2002)
Internship: University of Colorado School of Medicine CO (1999)
Ph.D.: Stanford University, Cancer Biology (1998)
M.D.: Stanford University (1998)
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Courses

2013-14

Scientific Focus

Current Research and Scholarly Interests

I am interested in the pathophysiology, natural history and treatment of patients with immune-mediated skin disease. In conjunction with Dr. Lorinda Chung, Assistant Professor of Rheumatology, we have developed a multi-disciplinary autoimmune skin disease clinic. This weekly clinic is dedicated to the management of patients with rheumatic skin disease, such as lupus erythematosus, scleroderma, dermatomyositis, vasculitis, and psoriasis/psoriatic arthritis.

Part of my research focus is to conduct clinical trials in patients with all types of immunologic skin disease. The skin is the only target organ in which you can actually visualize the direct effects of inflammation, without the need for surrogate markers. We are particularly interested in studying in vivo effects of targeted therapeutic agents in order to better understand the biology of different types of cutaneous inflammation. To this end, we conduct phase I, II, and III trials in patients with a diverse array of inflammatory skin diseases.

We are also creating a longitudinal clinical and tissue bank derived from patients seen in our clinics. One focus of this translational research effort is to understand the pathophysiology of dermatomyositis. This is a particularly challenging clinical model, as it is known to be associated with internal malignancy in up to 30% of patients. In addition, there is considerable heterogeneity between patients, in terms of skin versus muscle inflammation. We are using microarray technology to identify novel targets for disease as well as molecular signatures that will help clinicians to better manage their patients with this devastating disease. We believe that, from these studies, it will be possible to make accurate clinical predictions regarding: risk of internal malignancy, risk of lung disease, or response to various therapeutic agents.

Publications

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Publication Topics

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