Daniel Bernstein
Academic Appointments
- Professor, Pediatrics - Cardiology
- Member, Child Health Research Institute
- Member, Bio-X
- Member, Stanford Cancer Institute
Key Documents
Contact Information
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Clinical Offices
Heart Center 725 Welch Road Suite 120 Palo Alto, CA 94304 Tel Work (650) 721-2121 Fax (650) 497-8422Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information Email Tel (650) 723-7913Alternate Contact Kari Costa Administrative Assistant EmailNot for medical emergencies or patient use
Professional Overview
Clinical Focus
- Pediatric Cardiology
- Pediatric Heart Transplantation
- Pediatric Heart Failure
Administrative Appointments
- Chief, Division of Pediatric Cardiology, Stanford University (1994 - 2011)
- Director, Children's Heart Center, Packard Children's Hospital at Stanford (2001 - 2011)
Honors and Awards
- Alfred Woodley Salter and Mabel G. Salter Endowed Professor of Pediatrics, Stanford University (April 2004-present)
Professional Education
| Residency: | Montefiore Medical Center/Albert Einstein COM NY (1982) |
| Board Certification: | General Pediatrics, American Board of Pediatrics (1984) |
| Internship: | Montefiore Medical Center/Albert Einstein COM NY (1979) |
| Board Certification: | Pediatric Cardiology, American Board of Pediatrics (1985) |
| Fellowship: | UCSF Medical Center CA (1986) |
| Fellowship: | Albert Einstein College of Medicine NY (1983) |
Internet Links
Scientific Focus
Current Research Interests
Our lab has several major focuses:
1. The role of the G protein coupled receptors in regulating cardiac function, and specifically mitochondrial structure and function.
2. Differences between right and left ventricular responses to stress and in their modes of failure, including gene expression and miR regulation.
3. Using iPSC-derived myocytes to understand heart failure and congenital heart disease.
4. We develop tools for evaluation of cardiovascular physiology in transgenic and knockout mice and in isolated cardiomyocytes.ce.
Specific projects underway in our lab include:
1. Evaluation of the role of beta1 and beta2 adrenergic receptor subtypes in regulating cardiac structure and function by studying mice with targeted gene disruption of these receptors. Evaluation of the role of crosstalk between beta receptors and other signaling pathways in regulating cardiac structure and function.
2. Role of beta receptors in regulation of mitochondrial structure and function, including processes of mitofusion, mitofission, autophagy and mitophagy.
3. Role of beta receptors in adriamycin cardiotoxicity.
4. Differences between the right and left ventricles in their responses to stresses such as increased afterload and increased preload, including gene expression and gene regulation by micro-RNAs.
5. Using patient-derived iPSC-cardiomyocytes to understand the mechanisms of cardiomyopathies common in children. Evaluation of mitochondrial function in iPSC-CMs and the ability of these cells to recapitulate mitochondrial abnormalities seen in patients with cardiomyopathy. Using iPSC-CMs to understand the mechanisms of heart failure in congenital heart disease, specifically in patients with systemic right ventricles.
6. Development of micro-engineered platforms for assessment of biomechanics of single native or iPSC-derived cardiomyocytes.
We also are interested in clinical cardiac transplantation in children, specifically:
1. Understanding the mechanisms of antibody mediated rejection.
2. Development of biomarkers for the detection and monitoring of post-transplant lymphoproliferative disorder in pediatric transplant patients.
Publications
- Abdominal complaints as a common first presentation of heart failure in adolescents with dilated cardiomyopathy. Am J Emerg Med. 2013; (4): 684-6
- Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development. Proc Natl Acad Sci U S A. 2013; (5): 1738-43
- Intermediate-term outcomes after combined heart-liver transplantation in children with a univentricular heart. J Heart Lung Transplant. 2013; (3): 368-70
- Sacrificial layer technique for axial force post assay of immature cardiomyocytes. Biomed Microdevices. 2013; (1): 171-81
- Dynamic microRNA expression during the transition from right ventricular hypertrophy to failure. Physiol Genomics. 2012; (10): 562-75
- In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium. Arterioscler Thromb Vasc Biol. 2012; (1): 92-102
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