Anson Lowe
Academic Appointments
- Associate Professor, Medicine - Gastroenterology & Hepatology
- Member, Stanford Cancer Institute
- Associate Professor (By courtesy), Molecular & Cellular Physiology
Key Documents
Contact Information
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Clinical Offices
Gastroenterology Clinic 900 Blake Wilbur Dr Garden Level MC 5355 Palo Alto, CA 94304 Tel Work (650) 736-5555 Fax (650) 498-6323
- Academic Offices
Personal Information Email Tel (650) 725-3372 Tel (650) 725-6764Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Gastroenterology
Professional Education
| Residency: | Presbyterian Hospital NY (1983) |
| Board Certification: | Gastroenterology, American Board of Internal Medicine (1987) |
| Fellowship: | UCSF Medical Center CA (1989) |
| Fellowship: | Columbia University School of Public Health NY (1984) |
| Board Certification: | Internal Medicine, American Board of Internal Medicine (1983) |
| Internship: | Presbyterian Hospital NY (1981) |
Internet Links
Scientific Focus
Current Research Interests
My laboratory is focused on the biology of the pancreas and esophagus and their associated diseases. Using animal models and materials from human subjects, we have used DNA microarrays to characterize the gene expression profile of acute pancreatitis, pancreatic cancer, and esophageal cancer. The resultant data has led to a focus on the development of diagnostic assays and the identification of novel genes that participate in disease pathogenesis. We currently utilize a variety of cellular and molecular approaches in cell lines and animal models to explore the role of specific genes in disease.
The gene, AGR2, is currently a major focus of the laboratory. AGR2 is highly expressed in many adenocarcinomas, including those derived from the esophagus, pancreas, breast, prostate, and lung. We recently established that AGR2 promotes tumor growth. Current efforts are focused on determining AGR2s mechanism of action in normal tissues and cancers, which we believe will lead to opportunities for the development of new therapies.
Publications
- CITED2 is a novel direct effector of peroxisome proliferator-activated receptor γ in suppressing hepatocellular carcinoma cell growth. Cancer. 2013; (6): 1217-26
- Loss of anterior gradient 2 (Agr2) expression results in hyperplasia and defective lineage maturation in the murine stomach. J Biol Chem. 2013; (6): 4321-33
- AGR2 gene function requires a unique endoplasmic reticulum localization motif. J Biol Chem. 2012; (7): 4773-82
- Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cysts. BMC Gastroenterol. 2012: 15
- Immunohistochemical panel for distinguishing esophageal adenocarcinoma from squamous cell carcinoma: a combination of p63, cytokeratin 5/6, MUC5AC, and anterior gradient homolog 2 allows optimal subtyping. Hum Pathol. 2012; (11): 1799-807
- PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells. Biochem Biophys Res Commun. 2012; (1): 183-7
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