Clinical Focus

• Hematopathology
• Pathology and Laboratory Medicine
• Anatomic/Clinical Pathology

Administrative Appointments

• Co-Director, Immunodiagnosis Laboratory, Stanford (2005 - present)
• Associate Chair for Hematopathology, Stanford (2009 - present)
• Associate Chair for Faculty Development and Diversity, Stanford (2009 - present)

Professional Education

Graduate & Fellowship Program Affiliations

• Pathology

Community and International Work

• Improving Pathology Facilities in Underserved Communities, Sri Lanka 

Current Research Interests

My laboratory studies the tissue expression pattern of proteins that are of potential interest for the diagnosis, prognostic stratification and therapy of patients with lymphoma and leukemia. We are currently investigating prognostic markers in diffuse large B-cell lymphoma such that risk groups can be better defined. We are also interested in the immunodiagnostic and molecular characterization of rare and aggressive hematopoietic tumors such as Natural Killer/T-cell lymphomas, histiocytic malignancies and childhood lymphomas.

Clinical Trials

• Genome, Proteome and Tissue Microarray in Childhood Acute Leukemia Recruiting
• Phase II study of Atorvastatin safety and antitumor effects in non-Hodgkin's Lymphoma Recruiting
• Phase I Intratumoral Dendritic Cell Immunotherapy in Thermally Ablated Liver Metastases Terminated
• Phase I/II Intratumoral DC Immunotherapy With Gemcitabine & XRT in Unresectable Pancreatic Cancer Completed
• Phase II Fludarabine, Cytoxan and FCCAM in Untreated B-Cell Chronic Lymphocytic Leukemia Completed

Publications

• LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era. Cerhan JR, Natkunam Y, Morton LM, Maurer MJ, Asmann Y, Habermann TM, Vasef MA, Cozen W, Lynch CF, Allmer C, Slager SL, Lossos IS, Chanock SJ, Rothman N, Hartge P, Dogan A, Wang SS. Leuk Lymphoma. 2012
• The spectrum of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a description of 10 cases. Gualco G, Natkunam Y, Bacchi CE. Mod Pathol. 2012
• Clinicopathologic and molecular features of 122 Brazilian cases of nodal and extranodal NK/T-cell lymphoma, nasal type, with EBV subtyping analysis. Gualco G, Domeny-Duarte P, Chioato L, Barber G, Natkunam Y, Bacchi CE. Am J Surg Pathol. 2011; 35 (8): 1195-203
• HGAL protein expression persists in disorders of germinal center dissolution: potential role of HGAL in the germinal center microenvironment. Temmins C, Zhao S, Lossos IS, Natkunam Y. Appl Immunohistochem Mol Morphol. 2011; 19 (3): 266-72
• Immunostaining to identify molecular subtypes of diffuse large B-cell lymphoma in a population-based epidemiologic study in the pre-rituximab era. Morton LM, Cerhan JR, Hartge P, Vasef MA, Neppalli VT, Natkunam Y, Dogan A, Dave BJ, Jain S, Levy R, Lossos IS, Cozen W, Davis S, Schenk MJ, Maurer MJ, Lynch CF, Rothman N, Chatterjee N, Yu K, Staudt LM, Weisenburger DD, Wang SS. Int J Mol Epidemiol Genet. 2011; 2 (3): 245-52