Clinical Focus

• Pediatric Cardiology
• Congenital Heart Defects
• Pulmonary Hypertension
• Pulmonary Vascular Disease
• Pulmonary Vascular Abnormalities

Administrative Appointments

• Director, Pediatric Cardiology Inpatient Ward, Stanford University Medical Center (2011 - present)
• Director, Pediatric Cardiology Training Program, Stanford University Medical School (2009 - present)
• Director, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University Medical Center (2000 - present)

Professional Education

Postdoctoral Advisees

Seth Hollander,  Mary Martin,  Shreya Sheth,  Heather Sun

Graduate & Fellowship Program Affiliations

• Pediatrics
• Bioengineering

Current Research Interests

Research interests include (1) computer simulation and modeling of cardiovascular physiology with specific attention paid to congenital heart disease and its treatment, and (2) the evaluation and treatment of pulmonary hypertension/pulmonary vascular disease and structural abnormalities of the pulmonary arteries as seen, for example, in Alagille Syndrome.

In the area of computational modeling, projects are underway in three areas: (1) examination of alterations in blood flow and vessel mechanics caused by coarctation (narrowing) of the aorta and the use of computational modeling to compare surgical and transcatheter methods of treatment, (2) creation of a computational model of the entire pulmonary vascular tree and computational modeling of various disease states including pulmonary artery stenosis and pulmonary hypertension as a disease stratification tool and better predict responses to therapy, and (3) the use of computational modeling to examine flow characteristics and energy efficiency at rest and varying degrees of exercise in patients who have undergone total cavopulmonary connection.

Clinical Trials

• Extension Study to Evaluate the Long Term Safety and Tolerability of Ambrisentan in Children with Pulmonary Hypertension aged 8-17 Recruiting
• Safety and Efficacy Study of Ambrisentan for Treatment of Pulmonary Arterial Hypertension in Children Aged 8-17 Recruiting
• Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension (TOPP) Recruiting
• Management of acute pulmonary hypertensive crisis in children with known pulmonary arterial hypertension Recruiting

Publications

• A method for quantitative characterization of growth in the 3-D structure of rat pulmonary arteries. Razavi H, Dusch MN, Zarafshar SY, Taylor CA, Feinstein JA. Microvasc Res. 2012
• Computational fluid dynamic simulations for determination of ventricular workload in aortic arch obstructions. Coogan JS, Chan FP, Ladisa JF, Taylor CA, Hanley FL, Feinstein JA. J Thorac Cardiovasc Surg. 2012
• Hypoplastic left heart syndrome: current considerations and expectations. Feinstein JA, Benson DW, Dubin AM, Cohen MS, Maxey DM, Mahle WT, Pahl E, Villafañe J, Bhatt AB, Peng LF, Johnson BA, Marsden AL, Daniels CJ, Rudd NA, Caldarone CA, Mussatto KA, Morales DL, Ivy DD, Gaynor JW, Tweddell JS, Deal BJ, Furck AK, Rosenthal GL, Ohye RG, Ghanayem NS, Cheatham JP, Tworetzky W, Martin GR. J Am Coll Cardiol. 2012; 59 (1 Suppl): S1-42
• Computational simulations demonstrate altered wall shear stress in aortic coarctation patients treated by resection with end-to-end anastomosis. LaDisa JF, Dholakia RJ, Figueroa CA, Vignon-Clementel IE, Chan FP, Samyn MM, Cava JR, Taylor CA, Feinstein JA. Congenit Heart Dis. 2011 Sep-Oct; 6 (5): 432-43
• A rapid and computationally inexpensive method to virtually implant current and next-generation stents into subject-specific computational fluid dynamics models. Gundert TJ, Shadden SC, Williams AR, Koo BK, Feinstein JA, Ladisa JF. Ann Biomed Eng. 2011; 39 (5): 1423-37