Clinical Focus

• Radiology
• Pediatric Radiology
• Pediatric Oncology Imaging

Administrative Appointments

• Associate Editor/Contrast Media, Radiology (2011 - present)
• Elected Member, Board of Directors of the SPR, Society for Pediatric Radiology (2010 - present)
• NIH Study Section Member, Cancer Immunopathology and Immunotherapy Study Section (CII) (2010 - 2016)
• Molecular imaging scientific committee, Radiological Society of North America (2010 - 2012)
• International Outreach Committee, American College of Radiology (ACR) Foundation (2010 - present)

Honors and Awards

• Berdon Award for the best basic science paper, published in Pediatric Radiology in 2011, Society for Pediatric Radiology (2012)
• Research featured on the cover of the September issue, Clinical Cancer Research (2011)
• Author of the 10th and 17th most cited articles (out of 1,100 articles), Journal of Visualized Experiments (2011)
• Distinguished Reviewer, Journal of Magnetic Resonance Imaging, International Society for Magnetic Resonance in Medicine (2011)
• Editor's recognition award with special distinction for reviews for the journal Radiology, Radiology Editorial Board (2011)

Professional Education

Postdoctoral Advisees

Celina Ansari,  Rakhee Gawande,  Aman Khurana,  Hossein Nejadnik,  Qiaoyun Shi

Community and International Work

• Member of the American College of Radiology (ACR) Foundation International Outreach Committee 

Internet Links

• Daldrup-Link Lab Site

Current Research Interests

Cells are the basic units of life. They determine normal organ function and disease development. Observations of living cells are vital to understanding, diagnosing, and successfully treating disease. Developments of cell specific contrast agents have enabled us to develop non-invasive imaging techniques that can generate detailed information about specific cells in the body. Our research program focuses on two main cellular imaging applications
1. Cancer Imaging
2. Stem Cell Imaging
mostly utilizing MR imaging technology. We investigate the value of clinically applicable macrophage-targeted nanoparticles for the diagnosis and treatment of tumor-associated inflammation, we develop immune cell tracking techniques for diagnosing successful cancer immunotherapies and we explore the value of "smart", activatable cellular contrast agents for diagnosing successful or unsuccessful stem cell therapies. Currently, the diagnosis of diseases and their treatment almost always involves acquiring and repeating multiple imaging tests, which are time-consuming, cause direct and indirect accumulated expenses and accumulated radiation exposures. We ultimately aim to combine tailored cell specific contrast agents with whole body imaging techniques in order to create one single diagnostic test, which provides comprehensive "one-stop" evaluations of tumor and stem cell therapies.
Weblink: http://mips.stanford.edu/research/daldrup-link-lab.html

Clinical Trials

• Differentiation of Bone Sarcomas and Osteomyelitis with Ferumoxytol-Enhanced MRI Recruiting
• Pilot Development of Radiation Free Whole Body MR Imaging Technique for Staging Children w/ Cancer Recruiting

Publications

• Differentiation of Normal Thymus from Anterior Mediastinal Lymphoma and Lymphoma Recurrence at Pediatric PET/CT. Gawande RS, Khurana A, Messing S, Zhang D, Castañeda RT, Goldsby RE, Hawkins RA, Daldrup-Link HE. Radiology. 2012; 262 (2): 613-622
• Engineering stem cells for treatment of osteochondral defects. Nejadnik H, Daldrup-Link HE. Skeletal Radiol. 2012; 41 (1): 1-4
• MRI of tumor-associated macrophages with clinically applicable iron oxide nanoparticles. Daldrup-Link HE, Golovko D, Ruffell B, Denardo DG, Castaneda R, Ansari C, Rao J, Tikhomirov GA, Wendland MF, Corot C, Coussens LM. Clin Cancer Res. 2011; 17 (17): 5695-704
• Magnetic Resonance Imaging of Ferumoxide-Labeled Mesenchymal Stem Cells in Cartilage Defects: In Vitro and In Vivo Investigations. Henning TD, Gawande R, Khurana A, Tavri S, Mandrussow L, Golovko D, Horvai A, Sennino B, McDonald D, Meier R, Wendland M, Derugin N, Link TM, Daldrup-Link HE. Mol Imaging. 2011
• Monitoring of natural killer cell immunotherapy using noninvasive imaging modalities. Jha P, Golovko D, Bains S, Hostetter D, Meier R, Wendland MF, Daldrup-Link HE. Cancer Res. 2010; 70 (15): 6109-13