Clinical Focus

• Cardiology
• Inherited cardiovascular disease
• Heart Failure
• Genomic medicine
• Hypertrophic Cardiomyopathy

Administrative Appointments

• Director, Stanford Center for Inherited Cardiovascular Disease (2010 - present)
• Deputy Director, Stanford Cardiovascular Institute (2010 - present)
• Director, Stanford Cardiopulmonary Exercise Testing Laboratory (2007 - present)
• Co-Director, Stanford Research Training Program in Myocardial Biology (2010 - present)
• Director, Stanford Hypertrophic Cardiomyopathy Center (2006 - present)

Honors and Awards

• NIH Director's New Innovator Award, National Institutes of Health (2009)
• Innovative Research Award, American Heart Association (2008)
• Faculty Scholar, Donald E. and Delia B. Baxter Foundation (2009)
• Career Development Award (K08), National Institutes of Health (2006)
• Western Affiliates Young Investigator Award, American Heart Association (2004)

Professional Education

Postdoctoral Advisees

Frederick Dewey,  Stephen Pan,  Christopher Woods,  Kathia Zaleta Rivera

Graduate & Fellowship Program Affiliations

• Biomedical Informatics
• Genetics
• Medicine
• Molecular and Genetic Medicine
• Cardiovascular Medicine

Community and International Work

• Arbor Free Cardiology Clinic 

Internet Links

• Ashley Lab website

Current Research Interests

We are interested in the molecular genetics of myocardial adaptation - the response of the heart to exercise or disease stress. We take an integrative approach, using high dimensional genomic analysis to identify gene expression networks then use wet bench tools to assay the biological systems. We have a particular interest in the application of next generation sequencing to clinical medicine.

Clinical Trials

• Randomized Exercise Study including patients with hypertrophic cardiomyopathy Recruiting

Publications

• Gene coexpression network topology of cardiac development, hypertrophy, and failure. Dewey FE, Perez MV, Wheeler MT, Watt C, Spin J, Langfelder P, Horvath S, Hannenhalli S, Cappola TP, Ashley EA. Circ Cardiovasc Genet. 2011; 4 (1): 26-35
• Interpretation of the electrocardiogram of young athletes. Uberoi A, Stein R, Perez MV, Freeman J, Wheeler M, Dewey F, Peidro R, Hadley D, Drezner J, Sharma S, Pelliccia A, Corrado D, Niebauer J, Estes NA, Ashley E, Froelicher V. Circulation. 2011; 124 (6): 746-57
• Performance comparison of whole-genome sequencing platforms. Lam HY, Clark MJ, Chen R, Chen R, Natsoulis G, O'Huallachain M, Dewey FE, Habegger L, Ashley EA, Gerstein MB, Butte AJ, Ji HP, Snyder M. Nat Biotechnol. 2011; 30 (1): 78-82
• Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. Dewey FE, Chen R, Cordero SP, Ormond KE, Caleshu C, Karczewski KJ, Whirl-Carrillo M, Wheeler MT, Dudley JT, Byrnes JK, Cornejo OE, Knowles JW, Woon M, Sangkuhl K, Gong L, Thorn CF, Hebert JM, Capriotti E, David SP, Pavlovic A, West A, Thakuria JV, Ball MP, Zaranek AW, Rehm HL, Church GM, West JS, Bustamante CD, Snyder M, Altman RB, Klein TE, Butte AJ, Ashley EA. PLoS Genet. 2011; 7 (9): e1002280
• Challenges in the clinical application of whole-genome sequencing. Ormond KE, Wheeler MT, Hudgins L, Klein TE, Butte AJ, Altman RB, Ashley EA, Greely HT. Lancet. 2010; 375 (9727): 1749-51